| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ephrin type-A receptor 4 |
|---|
| Ligand | BDBM223311 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1798955 (CHEMBL4271247) |
|---|
| Kd | 420±n/a nM |
|---|
| Citation |  Lodola, A; Giorgio, C; Incerti, M; Zanotti, I; Tognolini, M Targeting Eph/ephrin system in cancer therapy. Eur J Med Chem142:152-162 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ephrin type-A receptor 4 |
|---|
| Name: | Ephrin type-A receptor 4 |
|---|
| Synonyms: | EPHA4 | EPHA4_HUMAN | Ephrin receptor | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 109859.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586961 |
|---|
| Residue: | 986 |
|---|
| Sequence: | MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS
KYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
|
|
|
|---|
| BDBM223311 |
|---|
| n/a |
|---|
| Name | BDBM223311 |
|---|
| Synonyms: | 123C4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H47ClN8O6 |
|---|
| Mol. Mass. | 807.336 |
|---|
| SMILES | COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
