| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50026273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54965 |
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| IC50 | 4.8±n/a nM |
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| Citation |  Hynes, JB; Harmon, SJ; Floyd, GG; Farrington, M; Hart, LD; Gale, GR; Washtien, WL; Susten, SS; Freisheim, JH Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid. J Med Chem28:209-15 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50026273 |
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| n/a |
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| Name | BDBM50026273 |
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| Synonyms: | 2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL305177 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6O5 |
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| Mol. Mass. | 438.4366 |
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| SMILES | Nc1nc(N)c2cc(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)ccc2n1 |
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| Structure | 
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