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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 3 | ||
| Ligand | BDBM50364378 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1800096 (CHEMBL4272388) | ||
| IC50 | 480±n/a nM | ||
| Citation |  Juillerat-Jeanneret, L; Aubert, JD; Mikulic, J; Golshayan, D Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem61:9811-9840 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 3 | |||
| Name: | Mitogen-activated protein kinase 3 | ||
| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 43136.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | curated by PDB 4QTB | ||
| Residue: | 379 | ||
| Sequence: |
| ||
| BDBM50364378 | |||
| n/a | |||
| Name | BDBM50364378 | ||
| Synonyms: | CHEMBL1950289 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23F3N6O2 | ||
| Mol. Mass. | 448.4415 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1 |r,wU:1.0,wD:4.7,25.26,(-6.26,-6.49,;-5.49,-5.16,;-6.25,-3.82,;-5.49,-2.5,;-3.95,-2.49,;-3.17,-3.82,;-3.94,-5.16,;-3.19,-1.16,;-1.65,-1.15,;-.89,.17,;.66,.18,;1.42,-1.15,;2.92,-1.46,;3.09,-2.98,;4.42,-3.75,;5.75,-2.97,;5.74,-1.45,;4.4,-.69,;7.06,-.67,;8.41,-1.43,;9.74,-.66,;8.41,-2.97,;7.08,-3.75,;7.08,-5.29,;1.69,-3.61,;1.23,-5.08,;-.23,-5.56,;-.23,-7.1,;1.24,-7.57,;2.14,-6.32,;.66,-2.48,;-.88,-2.48,)| | ||
| Structure | 
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