| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP15 |
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| Ligand | BDBM50468579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1800456 (CHEMBL4272748) |
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| IC50 | 2600±n/a nM |
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| Citation |  Murthy, S; Desantis, J; Verheugd, P; Maksimainen, MM; Venkannagari, H; Massari, S; Ashok, Y; Obaji, E; Nkizinkinko, Y; Lüscher, B; Tabarrini, O; Lehtiö, L 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem156:93-102 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP15 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP15 |
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| Synonyms: | (ARTD7 or PARP15) | (ARTD7 or PARP15, Y598L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 7 | ARTD7 | B-aggressive lymphoma protein 3 | BAL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD7 or PARP15, Y598L) | PAR15_HUMAN | PARP-15 | PARP15 | Poly [ADP-ribose] polymerase 15 | Synonyms=BAL3 |
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| Type: | n/a |
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| Mol. Mass.: | 74595.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q460N3 |
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| Residue: | 678 |
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| Sequence: | MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA
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| BDBM50468579 |
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| n/a |
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| Name | BDBM50468579 |
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| Synonyms: | CHEMBL4287262 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11NO4 |
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| Mol. Mass. | 257.2414 |
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| SMILES | NC(=O)c1ccc(Oc2ccc(cc2)C(O)=O)cc1 |
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| Structure | 
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