| Reaction Details |
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 | Report a problem with these data |
| Target | Guanine nucleotide-binding protein subunit alpha-11 |
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| Ligand | BDBM50468900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1801541 (CHEMBL4273833) |
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| IC50 | 1890±n/a nM |
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| Citation |  Zhang, H; Nielsen, AL; Boesgaard, MW; Harpsøe, K; Daly, NL; Xiong, XF; Underwood, CR; Haugaard-Kedström, LM; Bräuner-Osborne, H; Gloriam, DE; Strømgaard, K Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem156:847-860 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanine nucleotide-binding protein subunit alpha-11 |
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| Name: | Guanine nucleotide-binding protein subunit alpha-11 |
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| Synonyms: | G alpha-11 | G-protein subunit alpha-11 | GA11 | GNA11 | GNA11_HUMAN | Guanine nucleotide-binding protein G(y) subunit alpha | Guanine nucleotide-binding protein subunit alpha-11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42118.31 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117985 |
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| Residue: | 359 |
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| Sequence: | MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEK
VTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVL
RVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
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| BDBM50468900 |
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| n/a |
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| Name | BDBM50468900 |
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| Synonyms: | CHEMBL4282827 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H67N7O15 |
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| Mol. Mass. | 946.0514 |
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| SMILES | CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@H](COC1=O)NC(C)=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| |
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| Structure | 
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