Reaction Details |
| Report a problem with these data |
Target | 5'-nucleotidase |
---|
Ligand | BDBM18136 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1803170 (CHEMBL4275462) |
---|
IC50 | 23600±n/a nM |
---|
Citation | Dumontet, C; Peyrottes, S; Rabeson, C; Cros-Perrial, E; Géant, PY; Chaloin, L; Jordheim, LP CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates. Eur J Med Chem157:1051-1055 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5'-nucleotidase |
---|
Name: | 5'-nucleotidase |
Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
Type: | Enzyme |
Mol. Mass.: | 63371.54 |
Organism: | Homo sapiens (Human) |
Description: | P21589 |
Residue: | 574 |
Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
|
|
|
BDBM18136 |
---|
n/a |
---|
Name | BDBM18136 |
Synonyms: | ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid | alpha, beta-methyleneadenosine 5 -diphosphate | cid_92199 |
Type | Nucleoside or nucleotide |
Emp. Form. | C11H17N5O9P2 |
Mol. Mass. | 425.2283 |
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
Structure |
|