Reaction Details |
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Target | Small conductance calcium-activated potassium channel protein 1/2/3 |
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Ligand | BDBM50366799 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_200080 (CHEMBL805640) |
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IC50 | 7500±n/a nM |
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Citation | Galanakis, D; Calder, JA; Ganellin, CR; Owen, CS; Dunn, PM Synthesis and quantitative structure-activity relationships of dequalinium analogues as K+ channel blockers: investigation into the role of the substituent at position 4 of the quinoline ring. J Med Chem38:3536-46 (1995) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Small conductance calcium-activated potassium channel protein 1/2/3 |
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Name: | Small conductance calcium-activated potassium channel protein 1/2/3 |
Synonyms: | Small conductance calcium-activated potassium channel |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1559987 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Small conductance calcium-activated potassium channel protein 3 |
Synonyms: | KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel |
Type: | PROTEIN |
Mol. Mass.: | 81476.29 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_494975 |
Residue: | 732 |
Sequence: | MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ
LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI
LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK
YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA
THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA
RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR
VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV
AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK
HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL
ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST
SFPTPYTSSSSC
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Component 2 |
Name: | Small conductance calcium-activated potassium channel protein 1 |
Synonyms: | KCNN1_RAT | Kcnn1 | Potassium Channel, Ca2+ Act., VS | Sk1 | Small conductance calcium-activated potassium channel |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59231.59 |
Organism: | RAT |
Description: | Potassium Channel, Ca2+ Act., VS 0 RAT::P70606 |
Residue: | 536 |
Sequence: | MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRG
HSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTE
TELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWE
RVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARV
MLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVC
ERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAV
VARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQ
RKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAA
LESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
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Component 3 |
Name: | Small conductance calcium-activated potassium channel protein 2 |
Synonyms: | KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2) |
Type: | Protein |
Mol. Mass.: | 63876.72 |
Organism: | Rattus norvegicus (Rat) |
Description: | P70604 |
Residue: | 580 |
Sequence: | MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA
PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
IETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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BDBM50366799 |
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n/a |
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Name | BDBM50366799 |
Synonyms: | TUBOCURARINE | TUBOCURARINE CHLORIDE |
Type | Small organic molecule |
Emp. Form. | C37H41N2O6 |
Mol. Mass. | 609.7307 |
SMILES | COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4 |r| |
Structure |
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