| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50054811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_66550 (CHEMBL677817) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Ruenitz, PC; Bourne, CS; Sullivan, KJ; Moore, SA Estrogenic triarylethylene acetic acids: effect of structural variation on estrogen receptor affinity and estrogenic potency and efficacy in MCF-7 cells. J Med Chem39:4853-9 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | Estrogen receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 66549 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Estrogen receptor |
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| Synonyms: | ESR1_RAT | Esr | Esr1 | Estr | Nr3a1 | estrogen alpha |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 67045.89 |
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| Organism: | RAT |
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| Description: | estrogen alpha 0 RAT::P06211 |
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| Residue: | 600 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAY
EFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPP
HVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMI
MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK
SCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSP
LVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQG
KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI
HRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVP
LYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI
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| Component 2 |
| Name: | Estrogen receptor beta |
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| Synonyms: | ESR2_RAT | Erbeta | Esr2 | Estrogen receptor | Estrogen receptor beta | Nr3a2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59173.80 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_803011 |
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| Residue: | 530 |
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| Sequence: | MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPG
STSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVN
RETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVH
CLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTK
LADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEA
ESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ
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| BDBM50054811 |
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| n/a |
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| Name | BDBM50054811 |
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| Synonyms: | CHEMBL106773 | {4-[(Z)-1-(4-Hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22O4 |
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| Mol. Mass. | 374.4291 |
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| SMILES | CC\C(=C(/c1ccc(O)cc1)c1ccc(OCC(O)=O)cc1)c1ccccc1 |
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| Structure | 
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