| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1/2/3 |
|---|
| Ligand | BDBM50471141 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_164985 (CHEMBL774080) |
|---|
| IC50 | 13±n/a nM |
|---|
| Citation |  Baumgarth, M; Beier, N; Gericke, R (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem40:2017-34 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/hydrogen exchanger 1/2/3 |
|---|
| Name: | Sodium/hydrogen exchanger 1/2/3 |
|---|
| Synonyms: | Sodium/hydrogen exchanger |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 164985 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Sodium/hydrogen exchanger 1 |
|---|
| Synonyms: | NHE-1 | NHE1 | Na(+)/H(+) exchanger 1 | SL9A1_RABIT | SLC9A1 | Sodium/hydrogen exchanger 1 | Solute carrier family 9 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90725.96 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | ChEMBL_104865 |
|---|
| Residue: | 816 |
|---|
| Sequence: | MLLWSAVRGLSPPRIVPSLLVVVALAGLLPGLRSHGLQLSPTDSTTPDSQPSRERSIGDV
TTAPPEVTPESRPVNRSVTEHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGEKPPFLQSEVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYDHVGIVDIVLGFLSFFV
VALGGVFVGVVYGVIAAFTSRFTAHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKALPAERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITID
PASPQSPESVDLVNEELKGKVLGLSREPRVAEEAAEEDEDGGIVMRPKEPSSPGTDDVFS
PAPSDSPSSQRMQRCLSDPGPHPEPGEGEPFIPKGQ
|
|
|
|---|
| Component 2 |
| Name: | Sodium/hydrogen exchanger 2 |
|---|
| Synonyms: | NHE-2 | NHE2 | Na(+)/H(+) exchanger 2 | SL9A2_RABIT | SLC9A2 | Sodium/hydrogen exchanger 2 | Solute carrier family 9 member 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90773.04 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | ChEMBL_104865 |
|---|
| Residue: | 809 |
|---|
| Sequence: | MESAGTGRSLRTPPPRLLLLLLLQVAGPAGALAETLLNAPKAMGTSSSPLSPASVVAPGT
TAFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENLGTIFWYAVVGTLWN
SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTRVINWFR
TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
PLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDE
IREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESIRKDNSLNRERRA
STSTSRYLSLPKNTKLPEKLQKRKNISNADGDSSDSEADAGTTVLNLQPRARRFLPEPFS
KKASQAYKMEWKNEVDAGSGQGQPSPPAAPRSKEGGTQTPAVLRQPLLSKDQGREDSLTE
GGRPKPPPRLVRRASEPGNRKSRLGSDKP
|
|
|
|---|
| Component 3 |
| Name: | Sodium/hydrogen exchanger 3 |
|---|
| Synonyms: | NHE-3 | NHE3 | Na(+)/H(+) exchanger 3 | SL9A3_RABIT | SLC9A3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 92760.60 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | ChEMBL_104865 |
|---|
| Residue: | 832 |
|---|
| Sequence: | MSGRGGCGPCWGLLLALVLALGALPWTQGAEQEHHDEIQGFQIVTFKWHHVQDPYIIALW
VLVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLP
PIVLDAGYFMPNRLFFSNLGSILLYAVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDF
LLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFQSFVTLGGDK
VTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRVIEPGFVFIISYLSYLTS
EMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDP
LIWTWNTAFVLLTLLFVSVFRAIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFA
LVALLDGNKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHG
RAFDHILSAIEDISGQIGHNYLRDKWANFDRRFLSKLLMRQSAQKSRDRILNVFHELNLK
DAISYVTEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRESASAVCLDMQS
LEQRRRSVRDAEDVITHHTLQQYLYKPRQEYKHLYSRHVLSPSEDEKQDKEIFHRTMRKR
LESFKSAKLGLGQSKKATKHKRERERAQKRRNSSVPNGKLPLDSPAYGLTLKERELELSD
PEEAPDYYEAEKMSGGIEFLASVTKDTTSDSPAGIDNPVFSPDEDLAPSLLARVPPWLSP
GEAVVPSQRARVQIPYSPGNFRRLAPFRLSNKSVDSFLLAEDGAEHPESTHM
|
|
|
|---|
| BDBM50471141 |
|---|
| n/a |
|---|
| Name | BDBM50471141 |
|---|
| Synonyms: | CHEMBL304627 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16ClN3O4S |
|---|
| Mol. Mass. | 381.834 |
|---|
| SMILES | [#6]-c1cc(-[#8]-c2ccc(Cl)cc2)c(cc1-[#6](=O)\[#7]=[#6](/[#7])-[#7])S([#6])(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
