| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene B4 receptor 1/2 |
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| Ligand | BDBM50472423 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99657 (CHEMBL704423) |
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| IC50 | 6500±n/a nM |
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| Citation |  Poudrel, JM; Hullot, P; Vidal, JP; Girard, JP; Rossi, JC; Muller, A; Bonne, C; Bezuglov, V; Serkov, I; Renard, P; Pfeiffer, B Synthesis and structure-activity relationships of new 1, 3-disubstituted cyclohexanes as structurally rigid leukotriene B(4) receptor antagonists. J Med Chem42:5289-310 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene B4 receptor 1/2 |
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| Name: | Leukotriene B4 receptor 1/2 |
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| Synonyms: | Leukotriene B4 receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 88360 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Leukotriene B4 receptor 2 |
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| Synonyms: | BLT2R | BLTR2 | LT4R2_HUMAN | LTB4 receptor JULF2 | LTB4-R 2 | LTB4-R2 | LTB4R2 | LTB4R2 protein | Leukotriene B4 | Leukotriene B4 R2 | Leukotriene B4 receptor | Leukotriene B4 receptor 2 | Leukotriene B4 receptor BLT2 | Leukotriene b1 | Seven transmembrane receptor BLTR2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 37964.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene 2 0 HUMAN::Q9NPC1 |
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| Residue: | 358 |
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| Sequence: | MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATL
VLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRC
LAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAA
HLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPY
HAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAG
PRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
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| Component 2 |
| Name: | Leukotriene B4 receptor 1 |
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| Synonyms: | BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 37582.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15722 |
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| Residue: | 352 |
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| Sequence: | MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNL
ALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVA
RPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAF
HLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVV
NLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGF
VAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
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| BDBM50472423 |
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| n/a |
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| Name | BDBM50472423 |
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| Synonyms: | CHEMBL150744 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H34FNO2 |
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| Mol. Mass. | 375.52 |
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| SMILES | CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(F)CCCCc1ccccc1 |
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| Structure | 
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