Reaction Details |
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Target | Melatonin receptor type 1A |
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Ligand | BDBM85362 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105112 (CHEMBL715955) |
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Ki | 63±n/a nM |
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Citation | Spadoni, G; Balsamini, C; Diamantini, G; Tontini, A; Tarzia, G; Mor, M; Rivara, S; Plazzi, PV; Nonno, R; Lucini, V; Pannacci, M; Fraschini, F; Stankov, BM 2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists. J Med Chem44:2900-12 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1A |
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Name: | Melatonin receptor type 1A |
Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
Type: | Enzyme |
Mol. Mass.: | 39392.94 |
Organism: | Homo sapiens (Human) |
Description: | P48039 |
Residue: | 350 |
Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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BDBM85362 |
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n/a |
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Name | BDBM85362 |
Synonyms: | N-[(1H-Indol-2-yl)alkyl]acylamino Derivatives 5j |
Type | Small organic molecule |
Emp. Form. | C20H22N2O2 |
Mol. Mass. | 322.4009 |
SMILES | CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1 |
Structure |
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