Reaction Details |
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Target | Alpha-1A/Alpha-2A adrenergic receptor |
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Ligand | BDBM50027227 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_216440 (CHEMBL820155) |
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IC50 | 3±n/a nM |
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Citation | Watthey, JW; Gavin, T; Desai, M; Finn, BM; Rodebaugh, RK; Patt, SL Synthesis and biological properties of thiophene ring analogues of mianserin. J Med Chem26:1116-22 (1983) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1A/Alpha-2A adrenergic receptor |
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Name: | Alpha-1A/Alpha-2A adrenergic receptor |
Synonyms: | Cerebral cortex alpha adrenergic receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 30242 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51492.08 |
Organism: | CALF |
Description: | adrenergic Alpha1 0 CALF |
Residue: | 466 |
Sequence: | MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
AQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTL
HAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACT
TARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
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Component 2 |
Name: | Alpha-2A adrenergic receptor |
Synonyms: | ADA2A_BOVIN | ADRA2A | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha-2Da adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha2A | adrenergic Alpha2D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49275.13 |
Organism: | BOVINE |
Description: | adrenergic Alpha2 0 BOVINE::Q28838 |
Residue: | 452 |
Sequence: | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSG
QPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATA
AELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSS
EHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAK
ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCN
SSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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BDBM50027227 |
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n/a |
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Name | BDBM50027227 |
Synonyms: | 3-Methyl-1,2,3,4,4a,8-hexahydro-5-thia-3,12b-diaza-dibenzo[e,g]azulene | CHEMBL13645 |
Type | Small organic molecule |
Emp. Form. | C16H18N2S |
Mol. Mass. | 270.393 |
SMILES | CN1CCN2C(C1)c1sccc1Cc1ccccc21 |
Structure |
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