| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50106477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_137179 (CHEMBL745349) |
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| Ki | 1.9±n/a nM |
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| Citation |  Guerrini, R; Caló, G; Bigoni, R; Rizzi, D; Rizzi, A; Zucchini, M; Varani, K; Hashiba, E; Lambert, DG; Toth, G; Borea, PA; Salvadori, S; Regoli, D Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem44:3956-64 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | K3 opiate receptor | KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | Nociceptin/Orphanin FQ, NOP receptor | OPRX_MOUSE | ORGC | Oor | Oprl | Oprl1 | Orphanin FQ receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40499.09 |
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| Organism: | MOUSE |
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| Description: | Nociceptin/Orphanin FQ, NOP receptor 0 MOUSE::P35377 |
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| Residue: | 367 |
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| Sequence: | MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCI
GGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALC
KTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV
PVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR
GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRF
CTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTS
ETVPRPA
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| BDBM50106477 |
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| n/a |
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| Name | BDBM50106477 |
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| Synonyms: | CHEMBL265801 | FGGFTGARKSARKLADE | Phe-GGFTGARKSARKLAD-Glu |
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| Type | Small organic molecule |
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| Emp. Form. | C79H128N26O23 |
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| Mol. Mass. | 1810.022 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O |
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| Structure | 
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