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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 7 | ||
| Ligand | BDBM50098546 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3769 (CHEMBL620768) | ||
| Ki | 13±n/a nM | ||
| Citation |  López-Rodríguez, ML; Porras, E; Morcillo, MJ; Benhamú, B; Soto, LJ; Lavandera, JL; Ramos, JA; Olivella, M; Campillo, M; Pardo, L Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives. J Med Chem46:5638-50 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 7 | |||
| Name: | 5-hydroxytryptamine receptor 7 | ||
| Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 49852.62 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Rat cloned 5-HT7R. | ||
| Residue: | 448 | ||
| Sequence: |
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| BDBM50098546 | |||
| n/a | |||
| Name | BDBM50098546 | ||
| Synonyms: | (R)-11-(2,6-Dimethoxy-phenyl)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | CHEMBL283065 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H25NO2 | ||
| Mol. Mass. | 371.4715 | ||
| SMILES | COc1cccc(OC)c1-c1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12 |wD:16.17,(7.32,-7.03,;8.71,-7.68,;9.98,-6.81,;9.85,-5.28,;11.11,-4.41,;12.5,-5.06,;12.63,-6.59,;14.14,-6.11,;14.33,-4.57,;11.35,-7.46,;11.39,-9.18,;10.07,-9.94,;10.07,-11.48,;11.39,-12.25,;12.73,-11.48,;14.07,-12.25,;15.39,-11.48,;16.72,-12.25,;16.7,-13.78,;18.06,-11.49,;18.06,-9.94,;16.75,-9.18,;16.75,-7.62,;15.41,-6.84,;14.07,-7.61,;14.07,-9.15,;15.41,-9.94,;12.73,-9.94,)| | ||
| Structure | 
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