| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 7 |
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| Ligand | BDBM50240359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_3768 (CHEMBL620767) |
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| Ki | 79±n/a nM |
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| Citation |  López-Rodríguez, ML; Porras, E; Morcillo, MJ; Benhamú, B; Soto, LJ; Lavandera, JL; Ramos, JA; Olivella, M; Campillo, M; Pardo, L Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives. J Med Chem46:5638-50 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 7 |
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| Name: | 5-hydroxytryptamine receptor 7 |
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| Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 49852.62 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cloned 5-HT7R. |
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| Residue: | 448 |
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| Sequence: | MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT
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| BDBM50240359 |
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| n/a |
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| Name | BDBM50240359 |
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| Synonyms: | 1-(5-(4-phenylpiperazin-1-yl)pentyl)benzo[cd]indol-2(1H)-one | 1-[5-(4-Phenyl-piperazin-1-yl)-pentyl]-1H-benzo[cd]indol-2-one | CHEMBL12259 | UCM-5600 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N3O |
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| Mol. Mass. | 399.528 |
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| SMILES | O=C1N(CCCCCN2CCN(CC2)c2ccccc2)c2cccc3cccc1c23 |
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| Structure | 
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