| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Ligand | BDBM50474857 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306799 (CHEMBL832384) |
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| IC50 | 130±n/a nM |
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| Citation |  Galanakis, D; Ganellin, CR; Chen, JQ; Gunasekera, D; Dunn, PM Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons. Bioorg Med Chem Lett14:4231-5 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Name: | Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Synonyms: | Small conductance calcium-activated potassium channel |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1559987 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Small conductance calcium-activated potassium channel protein 3 |
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| Synonyms: | KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel |
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| Type: | PROTEIN |
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| Mol. Mass.: | 81476.29 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_494975 |
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| Residue: | 732 |
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| Sequence: | MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ
LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI
LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK
YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA
THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA
RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR
VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV
AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK
HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL
ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST
SFPTPYTSSSSC
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| Component 2 |
| Name: | Small conductance calcium-activated potassium channel protein 1 |
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| Synonyms: | KCNN1_RAT | Kcnn1 | Potassium Channel, Ca2+ Act., VS | Sk1 | Small conductance calcium-activated potassium channel |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59231.59 |
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| Organism: | RAT |
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| Description: | Potassium Channel, Ca2+ Act., VS 0 RAT::P70606 |
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| Residue: | 536 |
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| Sequence: | MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRG
HSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTE
TELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWE
RVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARV
MLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVC
ERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAV
VARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQ
RKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAA
LESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
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| Component 3 |
| Name: | Small conductance calcium-activated potassium channel protein 2 |
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| Synonyms: | KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2) |
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| Type: | Protein |
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| Mol. Mass.: | 63876.72 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P70604 |
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| Residue: | 580 |
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| Sequence: | MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA
PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
IETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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| BDBM50474857 |
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| n/a |
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| Name | BDBM50474857 |
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| Synonyms: | CHEMBL185106 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4 |
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| Mol. Mass. | 384.5155 |
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| SMILES | C1CC[n+]2ccc(NCCCNc3cc[n+](C1)c1ccccc31)c1ccccc21 |
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| Structure | 
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