Ki Summary

Reaction Details

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Target

Nociceptin receptor

Ligand

BDBM50475327

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_313607 (CHEMBL835014)

EC50

1.1±n/a nM

Citation

Guerrini, R; Cal�, G; Lambert, DG; Carr�, G; Arduin, M; Barnes, TA; McDonald, J; Rizzi, D; Trapella, C; Marzola, E; Rowbotham, DJ; Regoli, D; Salvadori, S N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands. J Med Chem48:1421-7 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nociceptin receptor

Name:

Nociceptin receptor

Synonyms:

OOR | OPRL1 | OPRX_CAVPO

Type:

PROTEIN

Mol. Mass.:

40796.89

Organism:

Cavia porcellus

Description:

ChEMBL_444577

Residue:

370

Sequence:

MESLFPAPFWEVLYGSHLQGNLSLLSPNHSGLPPHLLLNASHSAFLPLGLKVTIVGLYLA
VCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQATDILLGFWPFGN
TLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALALV
VGVPVAIMGSAQVEDEEIECLVEIPDPQDYWGPVFAVSIFLFSFIIPVLIISVCYSLMIR
RLHGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETTVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVALGC
KTTETVPRPA

BDBM50475327

n/a

Name

BDBM50475327

Synonyms:

CHEMBL410653

Type

Small organic molecule

Emp. Form.

C82H141N35O21

Mol. Mass.

1953.2188

SMILES

[#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](=O)-[#7](-[#7])-[#7])-[#6](=O)-[#7]-[#7]

Structure