| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-2/beta-4 |
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| Ligand | BDBM50475822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_352119 (CHEMBL868992) |
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| Ki | 1700±n/a nM |
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| Citation |  Chellappan, SK; Xiao, Y; Tueckmantel, W; Kellar, KJ; Kozikowski, AP Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem49:2673-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-2/beta-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-2/beta-4 |
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| Synonyms: | Neuronal acetylcholine receptor Alpha-2/Beta-4 | Neuronal acetylcholine receptor protein alpha-2/beta-4 subunit | Neuronal acetylcholine receptor; alpha2/beta4 | nAChR subtypes alpha2 beta4 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-2 |
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| Synonyms: | ACHA2_RAT | Acra2 | Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4 | Chrna2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58597.25 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P12389 |
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| Residue: | 511 |
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| Sequence: | MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDV
VIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIP
DIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGS
WTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRR
LPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSL
VIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP
LPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYG
HGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAM
VVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
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| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit beta-4 |
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| Synonyms: | ACHB4_RAT | Acrb4 | Chrnb4 | N-alpha 2 | Neuronal acetylcholine receptor non-alpha-2
chain | Neuronal acetylcholine receptor protein beta-4 subunit |
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| Type: | Enzyme |
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| Mol. Mass.: | 55863.89 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P12392 |
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| Residue: | 495 |
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| Sequence: | MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELS
LSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNA
DGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEI
DMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLII
PCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLF
TMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPH
PSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSS
GRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGL
FLPPLFQIHAPSKDS
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| BDBM50475822 |
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| n/a |
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| Name | BDBM50475822 |
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| Synonyms: | CHEMBL208066 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N2OS |
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| Mol. Mass. | 286.392 |
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| SMILES | Cc1ccc(s1)-c1ccc2C3CNCC(C3)Cn2c1=O |
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| Structure | 
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