Reaction Details |
| Report a problem with these data |
Target | Tubulin beta chain |
---|
Ligand | BDBM50014846 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_422811 (CHEMBL856530) |
---|
IC50 | 1400±n/a nM |
---|
Citation | Zuse, A; Schmidt, P; Baasner, S; Böhm, KJ; Müller, K; Gerlach, M; Günther, EG; Unger, E; Prinz, H 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem49:7816-25 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tubulin beta chain |
---|
Name: | Tubulin beta chain |
Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
Type: | PROTEIN |
Mol. Mass.: | 49840.26 |
Organism: | Sus scrofa |
Description: | ChEMBL_105107 |
Residue: | 445 |
Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
|
|
|
BDBM50014846 |
---|
n/a |
---|
Name | BDBM50014846 |
Synonyms: | (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum |
Type | Small organic molecule |
Emp. Form. | C22H25NO6 |
Mol. Mass. | 399.437 |
SMILES | COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r| |
Structure |
|