Reaction Details |
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Target | Small conductance calcium-activated potassium channel protein 1/2/3 |
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Ligand | BDBM50476802 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_446338 (CHEMBL895448) |
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Ki | 35±n/a nM |
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Citation | Graulich, A; Dilly, S; Farce, A; Scuvée-Moreau, J; Waroux, O; Lamy, C; Chavatte, P; Seutin, V; Liégeois, JF Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers. J Med Chem50:5070-5 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Small conductance calcium-activated potassium channel protein 1/2/3 |
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Name: | Small conductance calcium-activated potassium channel protein 1/2/3 |
Synonyms: | Small conductance calcium-activated potassium channel |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1559987 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Small conductance calcium-activated potassium channel protein 3 |
Synonyms: | KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel |
Type: | PROTEIN |
Mol. Mass.: | 81476.29 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_494975 |
Residue: | 732 |
Sequence: | MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ
LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI
LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK
YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA
THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA
RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR
VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV
AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK
HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL
ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST
SFPTPYTSSSSC
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Component 2 |
Name: | Small conductance calcium-activated potassium channel protein 1 |
Synonyms: | KCNN1_RAT | Kcnn1 | Potassium Channel, Ca2+ Act., VS | Sk1 | Small conductance calcium-activated potassium channel |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59231.59 |
Organism: | RAT |
Description: | Potassium Channel, Ca2+ Act., VS 0 RAT::P70606 |
Residue: | 536 |
Sequence: | MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRG
HSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTE
TELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWE
RVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARV
MLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVC
ERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAV
VARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQ
RKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAA
LESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
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Component 3 |
Name: | Small conductance calcium-activated potassium channel protein 2 |
Synonyms: | KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2) |
Type: | Protein |
Mol. Mass.: | 63876.72 |
Organism: | Rattus norvegicus (Rat) |
Description: | P70604 |
Residue: | 580 |
Sequence: | MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA
PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
IETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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BDBM50476802 |
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n/a |
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Name | BDBM50476802 |
Synonyms: | CHEMBL395568 |
Type | Small organic molecule |
Emp. Form. | C34H38I2N2O6 |
Mol. Mass. | 824.4843 |
SMILES | [I-].[I-].COc1cc2cc[n+](C)c(Cc3ccccc3Cc3[n+](C)ccc4cc(OC)c(OC)c(OC)c34)c2c(OC)c1OC |
Structure |
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