| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Ligand | BDBM50048403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446338 (CHEMBL895448) |
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| Ki | 221±n/a nM |
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| Citation |  Graulich, A; Dilly, S; Farce, A; Scuvée-Moreau, J; Waroux, O; Lamy, C; Chavatte, P; Seutin, V; Liégeois, JF Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers. J Med Chem50:5070-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Name: | Small conductance calcium-activated potassium channel protein 1/2/3 |
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| Synonyms: | Small conductance calcium-activated potassium channel |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1559987 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Small conductance calcium-activated potassium channel protein 3 |
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| Synonyms: | KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel |
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| Type: | PROTEIN |
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| Mol. Mass.: | 81476.29 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_494975 |
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| Residue: | 732 |
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| Sequence: | MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ
LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI
LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK
YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA
THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA
RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR
VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV
AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK
HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL
ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST
SFPTPYTSSSSC
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| Component 2 |
| Name: | Small conductance calcium-activated potassium channel protein 1 |
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| Synonyms: | KCNN1_RAT | Kcnn1 | Potassium Channel, Ca2+ Act., VS | Sk1 | Small conductance calcium-activated potassium channel |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59231.59 |
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| Organism: | RAT |
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| Description: | Potassium Channel, Ca2+ Act., VS 0 RAT::P70606 |
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| Residue: | 536 |
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| Sequence: | MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRG
HSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTE
TELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWE
RVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARV
MLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVC
ERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAV
VARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQ
RKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAA
LESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
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| Component 3 |
| Name: | Small conductance calcium-activated potassium channel protein 2 |
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| Synonyms: | KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2) |
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| Type: | Protein |
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| Mol. Mass.: | 63876.72 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P70604 |
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| Residue: | 580 |
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| Sequence: | MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA
PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
IETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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| BDBM50048403 |
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| n/a |
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| Name | BDBM50048403 |
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| Synonyms: | 1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methylquinolinium) Diiodide Hydrate | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride ; Dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(Deq) | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(dequalinium) | CHEMBL121663 | DQ+ | Dequalinium chloride | Dequqlinium | GNF-Pf-5483 | dequalinium |
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| Type | Small organic molecule |
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| Emp. Form. | C30H40N4 |
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| Mol. Mass. | 456.6643 |
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| SMILES | Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12 |
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| Structure | 
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