Reaction Details |
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Target | 1,3-beta-glucan synthase |
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Ligand | BDBM50478216 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_472370 (CHEMBL952948) |
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IC50 | 25.7±n/a nM |
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Citation | Paderu, P; Garcia-Effron, G; Balashov, S; Delmas, G; Park, S; Perlin, DS Serum differentially alters the antifungal properties of echinocandin drugs. Antimicrob Agents Chemother51:2253-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,3-beta-glucan synthase |
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Name: | 1,3-beta-glucan synthase |
Synonyms: | GSL2 | Glucan synthase |
Type: | PROTEIN |
Mol. Mass.: | 189382.66 |
Organism: | Candida albicans |
Description: | ChEMBL_19912 |
Residue: | 1640 |
Sequence: | MFDYLMRLLDSRTSRLGPTHALRSIHADYIGGMNSNFRKWYFAAQLDIDDFVGFDNLAKN
GKIKGSNDPVATLEQAESQWSTNMLALSPTDSVIQLAIYLLIWGEANNIRFMPECICFIF
KCCNDFYFSIDPDTPVTTVTPSFLDHIITPLYNFYRDQSYILVDGKYRRRDKDHESVIGY
DDMNQLFWYSKGLERLVLADKKSRLMSLPPGERYEELNQVLWNRVFYKTFKENRGWSHVL
VNFHRVWIIHSAVFWYYTAFNSPTLYTKNYQPALDNQPTTQARLSVLAFGGVVAIVIDII
SLLFELRFIPRKWTGAQPVSKRLALLILALILNVGPSVYLFMFIPLNVQNTVGLVISAFQ
FSFSVIMVLYLSTVPLGRLFSKKPKANDRRFLPQRSFVTNFYSLAEGDRVASYGLWFAIF
VSKFIESYFFLTLSLRDPVRELSIMKMSRCAGEVWLGNWFCTRQPTIVLGLIYLTDLVLF
ILDTYLWYIVWNTVFSVCRSFYIGVSIWTPWRNIFSRLPKRIFSKIISVSGDKNIKSKLL
VSQVWNSIIISMYREHLISLEHVQKLIYKQIDNPGVEGDSVLKEPIFFVSQEDQTIKSSL
FQDQAEAQRRITFFAQSLSTPMPEVGPVHLMPSFTVLIPHYSEKITLSLREIIREEEQYS
HVTMLEYLKSLHPLEWSCFVKDTKLLAEEFETDSSSAEIKREKLDDLPYYSVGFKVATPE
YILRTRIWASLRSQTLYRTISGFMNYSRAIKLLFDVENPDSTKFGTENDKLEQAAIMAHR
KFRIITSMQRLKYFTPEEKENTEFLLRAYPELQICYLDEEVDEASGEIVYYSALVDGSCA
IMENGEREPKYRIRLSGNPILGDGKSDNQNHSLIFCRGEYIQLVDANQDNYLEECLKIRS
ILAEFEEATFPLDPYSTDLEGTESVYPVAIIGTREYIFSENIGILGDVAAGKEQTFGTLF
ARTLAHIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNVVLRGGRIKHCE
YMQCGKGRDLGFGSILNFTTKIGAGMGEQMLSREYFYMGTQLPLDRFLSFYYAHSGFHLN
NLFIMLSIHLFLLVGANLAALTSESTICEYDRFRPITDPKRPHGCYNLIPVVHWLQRCIF
SIFIVFVISFVPLAVQELTERGFYKAITRLGKQFASFSPLFEVFVCKIYAHSLSSDISIG
GARYLATGRGFATIRVPFATLYSRFAVESLYYGSICGLLIFYCSLSMWKLQLLYFWITIL
GLLICPFLYNPNQFSWNDFFLDYKECIQWFYRGNSKPRLSSWINFTRLKRSRIVGVKSKR
YSINEEIKVVSEVKPSRFKLIISESFLQLCVITLVGLAYLFTNSQNGSRGTYPVNSILRI
LIISFVPIGVNLVILIACFVVSISIGPIFTLFCKKFPSFVAAIAHLLAVANHVFFFELLW
LFQNWNFSVTVLGFALSALIQCWFLQMMTILLVSREFRHDRSNRSWWSGKWATAGLGWYI
ITQPMREAVCKLSEMSYFAGDLVATHIILFAQIPILLIPYADKWHTLMLFWLKPGNQIRP
RILSKRQKRRRRFQANLYLLIFLLGLILFSSIFVLPLIATKYFDIEFSEYIPEFFHPLFQ
PYDAPTNSKGLKKKLEIKHY
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BDBM50478216 |
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n/a |
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Name | BDBM50478216 |
Synonyms: | CHEBI:600520 | Micafungin | Mycamine |
Type | Small organic molecule |
Emp. Form. | C56H71N9O23S |
Mol. Mass. | 1270.274 |
SMILES | [H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](O)NC(=O)[C@]1([H])[C@@H](O)[C@@H](C)CN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)c(OS(O)(=O)=O)c1)[C@H](O)CC(N)=O)NC(=O)c1ccc(cc1)-c1cc(on1)-c1ccc(OCCCCC)cc1)[C@@H](C)O |
Structure |
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