| Reaction Details |
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 | Report a problem with these data |
| Target | Type IV secretion-like conjugative transfer relaxase protein TraI |
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| Ligand | BDBM50162816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_476076 (CHEMBL921466) |
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| Ki | 3.0±n/a nM |
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| Citation |  Lujan, SA; Guogas, LM; Ragonese, H; Matson, SW; Redinbo, MR Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proc Natl Acad Sci U S A104:12282-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type IV secretion-like conjugative transfer relaxase protein TraI |
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| Name: | Type IV secretion-like conjugative transfer relaxase protein TraI |
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| Synonyms: | 3.6.1.- | Type IV secretion-like conjugative transfer relaxase protein TraI | traI |
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| Type: | PROTEIN |
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| Mol. Mass.: | 192092.76 |
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| Organism: | Escherichia coli (strain SMS-3-5 / SECEC) |
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| Description: | ChEMBL_118445 |
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| Residue: | 1756 |
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| Sequence: | MMSIAQVRSAGSAGNYYTDKDNYYVLGSMGERWAGRGAEQLGLQGSVDKDVFTRLLEGRL
PDGADLSRMQDGSNKHRPGYDLTFSAPKSVSMMAMLGGDKRLIDAHNQAVDFAVRQVEAL
ASTRVMTDGQSETVLTGNLVMALFNHDTSRDQEPQLHTHAVVANVTQHNGEWKTLSSDKV
GKTGFIENVYANQIAFGRLYREKLKEQVEALGYETEVVGKHGMWEMPGVPVEAFSGRSQT
IREAVGEDASLKSRDVAALDTRKSKQHVDPEIKMTEWMQTLKETGFDIRAYRDAAEQRAY
TRTQTPGPASQDGPDVQQAVTQAIAGLSERKVQFTYTDVLARTVGILPPEAGVIERARAG
IDEAISREQLIPLDREKGLFTSGIHVLDELSVRALSRDIMKQNRVTVHPEKSVPRTAGYS
DAVSVLAQDRPSLAIVSGQGGAAGQRERVAELVMMAREQGREVQIIAADRRSQMNLKQDE
RLSGELITGRRQLLEGMAFTPGSTVIVDQGEKLSLKETLTLLDGAARHNVQVLITDSGQR
TGTGSALMAMKDAGVNTYRWQGGEQRPATIISEPDRNVRYARLAGDFAASVKAGEESVAQ
VSGVREQAILTQAIRSELKTQGVLGHQEVTMTALSPVWLDSRSRYLRDMYRPGMVMEQWN
PETRSHDRYVIDRVTAQSHSLTLRDAQGETQVVRISSLDSSWSLFRPEKMPVADGERLRV
TGKIPGLRVSGGDRLQVASVSEDAMTVVVPGRAEPASLPVADSPFTALKLENGWVETPGH
SVSDSAKVFAAVTQMAMDNATLNGLARSGRDVRLYSSLDETRTAEKLARHPSFTVVSEQI
KAHAGETSLETSISLQKAGLHTPAQQAIHLALPVLESKKLAFSMVDLLTEAKSFAAEGTG
FTELGGEINAQIKRGDLLYVDVAKGYGTGLLVSRASYEAEKSILRHILEGKEAVTPLMER
VPGELMEKLTSGQRAATRMILETSDRFTVVQGYAGVGKTTQFRAVMSAVNMLPESMRPRV
VGLGPTHRAVGEMRSAGVDAQTLASFLHDTQLQQRSGETPDFSNTLFLLDESSMVGNTDM
ARAYALIAAGGGRAVASGDTDQLQAIAPGQPFRLQQTRSAADVAIMKEIVRQTPELREAV
YNLINRDVERALSGLERVKPSQVPRLEGAWAPEHSVMEFSHSQEAKLAEAQQKAMLKGEA
FPDVPMTLYEAIVRDYTGRTPEAREQTLIVTHLNEDRRVLNSMIHDAREKAGELGKEQVM
VPVLNTANIRDGELRRLSTWETHRDALVLVDNVYHRIAGISKDDGLITLEDAEGNTRLIS
PREAVAEGVTLYTPDTIRVGTGDRMRFTKSDRERGYVANSVWTVTAVSGDSVTLSDGQQT
RVIRPGQERAEQHIDLAYAITAHGAQGASETFAIALEGTEGNRKQMAGFESAYVALSRMK
QHVQVYTDNRQGWTDAINNAVQKGTAHDVFEPKPDREVMNAERLFSTARELRDVAAGRAV
LRQAGLAGGDSPARFIAPGRKYPQPYVALPAFDRNGKSAGIWLNPLTTDDGNGLRGFSGE
GRVKGSGDAQFVALQGSRNGESLLADNMQEGVRIARDNPDSGVVVRIAGEGRPWNPGAIT
GGRVWGDIPDNSVQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEIVRKMAENKPDLP
DGKTEQAVREIAGQERDRAAITEREAALPESVLRESQREREAVREVARENLLQERLQQME
RDMVRDLQKEKTLGGD
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| BDBM50162816 |
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| n/a |
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| Name | BDBM50162816 |
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| Synonyms: | CHEMBL180570 | Medronic acid | Methylene diphsphonate | Phosphonomethyl-phosphonic acid | methylenediphosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | CH6O6P2 |
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| Mol. Mass. | 176.0023 |
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| SMILES | OP(O)(=O)CP(O)(O)=O |
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| Structure | 
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