| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 1B |
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| Ligand | BDBM50350470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_553662 (CHEMBL960455) |
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| IC50 | 4160±n/a nM |
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| Citation |  Davies, TA; Page, MG; Shang, W; Andrew, T; Kania, M; Bush, K Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother51:2621-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 1B |
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| Name: | Penicillin-binding protein 1B |
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| Synonyms: | CAZ10_03050 | Murein polymerase | PBP-1b | PBP1b | Penicillin-binding protein 1B | ponB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85500.33 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_105732 |
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| Residue: | 774 |
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| Sequence: | MTRPRSPRSRNSKARPAPGLNKWLSWALKLGLVGLVLLAGFAIYLDAVVQEKFSGRRWTI
PAKVYARPLELFNGLKLSREDFLRELDALGYRREPSVSGPGTVSVAASAVELNTRGFQFY
EGAEPAQRVRVRFNGNYVSGLSQANGKELAVARLEPLLIGGLYPAHHEDRILVKLDQVPT
YLIDTLVAVEDRDFWNHHGVSLKSVARAVWVNTTAGQLRQGGSTLTQQLVKNFFLSNERS
LSRKINEAMMAVLLELHYDKRDILESYLNEVFLGQDGQRAIHGFGLASQYFFSQPLAELK
LDQVALLVGMVKGPSYFNPRRYPDRALARRNLVLDVLAEQGVATQQEVDAAKLRPLGVTR
QGSMADSSYPAFLDLVKRQLRQDYRDEDLTEEGLRIFTSFDPILQEKAETSVNETLKRLS
GRKGVDQVEAAMVVTNPETGEIQALIGSRDPRFAGFNRALDAVRPIGSLIKPAVYLTALE
RPSKYTLTTWVQDEPFAVKGQDGQVWRPQNYDRRSHGTIFLYQGLANSYNLSTAKLGLDV
GVPNVLQTVARLGINRDWPAYPSMLLGAGSLSPMEVATMYQTIASGGFNTPLRGIRSVLT
ADGQPLKRYPFQVEQRFDSGAVYLVQNAMQRVMREGTGRSVYSQLPSSLTLAGKTGTSND
SRDSWFSGFGGDLQAVVWLGRDDNGKTPLTGATGALQVWASFMRKAHPQSLEMPMPENVV
MAWVDAQTGQGSAADCPNAVQMPYIRGSEPAQGPGCGSQNPAGEVMDWVRGWLN
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| BDBM50350470 |
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| n/a |
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| Name | BDBM50350470 |
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| Synonyms: | CEFEPIME | Maxipime |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N6O5S2 |
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| Mol. Mass. | 480.561 |
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| SMILES | CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[N+]3(C)CCCC3)=C(N2C1=O)C([O-])=O)c1csc(N)n1 |r,c:19| |
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| Structure | 
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