| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50012278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495611 (CHEMBL1000303) |
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| IC50 | 130±n/a nM |
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| Citation |  Prinz, H; Schmidt, P; Böhm, KJ; Baasner, S; Müller, K; Unger, E; Gerlach, M; Günther, EG 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem52:1284-94 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49840.26 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_105107 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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| BDBM50012278 |
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| n/a |
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| Name | BDBM50012278 |
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| Synonyms: | (2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE | CHEMBL159 | VINBLASTINE | VINBLASTINE SULFATE | cid_5388983 |
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| Type | Small organic molecule |
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| Emp. Form. | C46H58N4O9 |
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| Mol. Mass. | 810.9741 |
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| SMILES | CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC |r,c:48| |
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| Structure | 
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