Ki Summary

Reaction Details

Report a problem with these data

Target

Bifunctional dihydrofolate reductase-thymidylate synthase

Ligand

BDBM18512

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_521654 (CHEMBL998901)

0.850000±n/a nM

Citation

Japrung, D; Leartsakulpanich, U; Chusacultanachai, S; Yuthavong, Y Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination. Antimicrob Agents Chemother51:4356-60 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Bifunctional dihydrofolate reductase-thymidylate synthase

Name:

Bifunctional dihydrofolate reductase-thymidylate synthase

Synonyms:

Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) | PfDHFR-TS

Type:

Enzyme

Mol. Mass.:

71741.43

Organism:

Plasmodium falciparum (isolate K1 / Thailand)

Description:

PfDHFR-TS wild-type (TM4/8.2) was expressed and purified from E. coli.

Residue:

608

Sequence:

MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCA
VTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTSWESIPKKFKPLS
NRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIK
KIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCI
KGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE
EKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKF
DLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH
REVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVK
DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP
AQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE
KISMDMAA

BDBM18512

n/a

Name

BDBM18512

Synonyms:

5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL36 | Pyrimethamine (Pyr) | US11530198, Example Pyrimethamine | cid_4993

Type

Small organic molecule

Emp. Form.

C12H13ClN4

Mol. Mass.

248.711

SMILES

CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1

Structure