Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM1737 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_545024 (CHEMBL1016320) |
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IC50 | 5701643±n/a nM |
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Citation | Hu, R; Doucet, JP; Delamar, M; Zhang, R QSAR models for 2-amino-6-arylsulfonylbenzonitriles and congeners HIV-1 reverse transcriptase inhibitors based on linear and nonlinear regression methods. Eur J Med Chem44:2158-71 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM1737 |
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n/a |
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Name | BDBM1737 |
Synonyms: | 2-Amino-6-arylthiobenzonitrile deriv. 1g | 2-amino-6-[(4-methylphenyl)sulfanyl]benzonitrile |
Type | Small organic molecule |
Emp. Form. | C14H12N2S |
Mol. Mass. | 240.323 |
SMILES | Cc1ccc(Sc2cccc(N)c2C#N)cc1 |
Structure |
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