| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50028536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54593 |
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| Ki | 0.002900±n/a nM |
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| Citation |  Piper, JR; Montgomery, JA; Sirotnak, FM; Chello, PL Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism. J Med Chem25:182-7 (1982) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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|
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| BDBM50028536 |
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| n/a |
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| Name | BDBM50028536 |
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| Synonyms: | 4-(Carboxymethyl-carbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid | CHEMBL52715 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N9O6 |
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| Mol. Mass. | 511.4906 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(=O)NCC(O)=O)C(O)=O |
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| Structure | 
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