| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50482922 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_675616 (CHEMBL1273924) |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Williams, PD; Staas, DD; Venkatraman, S; Loughran, HM; Ruzek, RD; Booth, TM; Lyle, TA; Wai, JS; Vacca, JP; Feuston, BP; Ecto, LT; Flynn, JA; DiStefano, DJ; Hazuda, DJ; Bahnck, CM; Himmelberger, AL; Dornadula, G; Hrin, RC; Stillmock, KA; Witmer, MV; Miller, MD; Grobler, JA Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold. Bioorg Med Chem Lett20:6754-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | pol |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32203.43 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_106649 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50482922 |
|---|
| n/a |
|---|
| Name | BDBM50482922 |
|---|
| Synonyms: | CHEMBL1270317 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H14N2O2 |
|---|
| Mol. Mass. | 314.3374 |
|---|
| SMILES | On1c2ncccc2c(cc1=O)-c1cccc(c1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
