| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peptidase |
|---|
| Ligand | BDBM50213266 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_677727 (CHEMBL1280505) |
|---|
| IC50 | 567000±n/a nM |
|---|
| Citation |  Koga, T; Masuda, N; Kakuta, M; Namba, E; Sugihara, C; Fukuoka, T Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrob Agents Chemother52:2849-54 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peptidase |
|---|
| Name: | Peptidase |
|---|
| Synonyms: | MecA | Pbp2a | Penicillin binding protein 2 prime | Penicillin binding protein 2' | Penicillin binding protein 2a (PBP2a) | Penicillin-binding protein 2 prime | Penicillin-binding protein 2' |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 76113.18 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_677175 |
|---|
| Residue: | 668 |
|---|
| Sequence: | MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEV
EMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKED
GMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSK
KDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVT
IVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLAL
VSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLD
DKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALEN
NGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGT
AELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENG
NKKYDIDE
|
|
|
|---|
| BDBM50213266 |
|---|
| n/a |
|---|
| Name | BDBM50213266 |
|---|
| Synonyms: | CHEBI:471744 | Imipenem | MK-0787 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H17N3O4S |
|---|
| Mol. Mass. | 299.346 |
|---|
| SMILES | [H][C@]12CC(SCCNC=N)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O |r,c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
