| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 2B |
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| Ligand | BDBM50022787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_706041 (CHEMBL1662855) |
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| IC50 | 466±n/a nM |
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| Citation |  Kosowska-Shick, K; McGhee, P; Appelbaum, PC Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Antimicrob Agents Chemother53:2176-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 2B |
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| Name: | Penicillin-binding protein 2B |
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| Synonyms: | PBP2_STRPN | Penicillin-binding protein 2B | pbp2b | pbp2b | penA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73859.38 |
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| Organism: | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
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| Description: | ChEMBL_103544 |
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| Residue: | 680 |
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| Sequence: | MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSAR
GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYY
LADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQ
LNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
KAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE
EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSG
IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAP
INSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRS
TFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGV
RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT
GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG
VGPSIARDIINLYQKYHPMN
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| BDBM50022787 |
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| n/a |
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| Name | BDBM50022787 |
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| Synonyms: | (+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G) | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion (Penicillin G) | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G) | BICILLIN | PENICILLIN G | PENICILLIN G PROCAINE | PENICILLIN-2 | PERMAPEN | PFIZERPEN | PFIZERPEN-AS | benzylpenicillin |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N2O4S |
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| Mol. Mass. | 334.39 |
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| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O |r| |
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| Structure | 
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