| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 1A |
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| Ligand | BDBM50213266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_706006 (CHEMBL1662820) |
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| IC50 | 86.9±n/a nM |
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| Citation |  Kosowska-Shick, K; McGhee, P; Appelbaum, PC Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Antimicrob Agents Chemother53:2176-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 1A |
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| Name: | Penicillin-binding protein 1A |
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| Synonyms: | 2.4.1.129 | 3.4.16.4 | DD-transpeptidase | PBP-1A | PBPA_STRPN | Penicillin-binding protein 1A | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | ponA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79749.99 |
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| Organism: | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
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| Description: | ChEMBL_103552 |
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| Residue: | 719 |
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| Sequence: | MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQ
GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYT
NVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQ
AVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNIT
LQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASS
EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLT
YGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYS
NRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWNSPA
PQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
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| BDBM50213266 |
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| n/a |
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| Name | BDBM50213266 |
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| Synonyms: | CHEBI:471744 | Imipenem | MK-0787 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N3O4S |
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| Mol. Mass. | 299.346 |
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| SMILES | [H][C@]12CC(SCCNC=N)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O |r,c:9| |
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| Structure | 
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