| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha'/beta |
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| Ligand | BDBM50335638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_794696 (CHEMBL1937305) |
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| Ki | 0.220000±n/a nM |
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| Citation |  Haddach, M; Pierre, F; Regan, CF; Borsan, C; Michaux, J; Stefan, E; Kerdoncuff, P; Schwaebe, MK; Chua, PC; Siddiqui-Jain, A; Macalino, D; Drygin, D; O'Brien, SE; Rice, WG; Ryckman, DM Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs. Bioorg Med Chem Lett22:45-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha'/beta |
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| Name: | Casein kinase II subunit alpha'/beta |
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| Synonyms: | Casein kinase II alpha''''/ beta | Casein kinase II alpha''/ beta | Casein kinase II alpha'/ beta |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 794696 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Casein kinase II subunit beta |
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| Synonyms: | CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 24937.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P67870 |
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| Residue: | 215 |
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| Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
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| Component 2 |
| Name: | Casein kinase II subunit alpha' |
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| Synonyms: | CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2) |
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| Type: | Protein |
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| Mol. Mass.: | 41223.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 350 |
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| Sequence: | MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
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| BDBM50335638 |
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| n/a |
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| Name | BDBM50335638 |
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| Synonyms: | 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | CHEMBL1230165 | US8168651, Compound TABLE 16.17 | US9062043, Table 13, Compound 17 | US9062043, Table 20b, Compound 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12ClN3O2 |
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| Mol. Mass. | 349.77 |
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| SMILES | OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 |
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| Structure | 
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