| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor 7-like 2 |
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| Ligand | BDBM50484960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_813063 (CHEMBL2020637) |
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| IC50 | >5000±n/a nM |
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| Citation |  Mao, Y; Lin, N; Tian, W; Han, X; Han, X; Huang, Z; An, J Design, synthesis, and biological evaluation of new diaminoquinazolines as ?-catenin/Tcf4 pathway inhibitors. J Med Chem55:1346-59 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor 7-like 2 |
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| Name: | Transcription factor 7-like 2 |
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| Synonyms: | HMG box transcription factor 4 | T-cell factor 4 | T-cell-specific transcription factor 4 | TCF-4 | TCF4 | TCF7L2 | TF7L2_HUMAN | hTCF-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67939.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107937 |
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| Residue: | 619 |
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| Sequence: | MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP
AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS
PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP
HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY
MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR
DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPC
RRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKP
DPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSH
SSLAGTQPQPLSLVTKSLE
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| BDBM50484960 |
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| n/a |
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| Name | BDBM50484960 |
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| Synonyms: | CHEMBL2018618 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27FN6O |
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| Mol. Mass. | 470.5413 |
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| SMILES | CC1CN(CCN1)c1nc(NCc2ccc(cc2)C(=O)Nc2ccc(F)cc2)c2ccccc2n1 |
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| Structure | 
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