| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 6 |
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| Ligand | BDBM50001103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_838470 (CHEMBL2076041) |
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| IC50 | 28000±n/a nM |
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| Citation |  Cihlar, T; Ho, ES Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem283:49-55 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 6 |
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| Name: | Solute carrier family 22 member 6 |
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| Synonyms: | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61831.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487359 |
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| Residue: | 563 |
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| Sequence: | MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL
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| BDBM50001103 |
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| n/a |
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| Name | BDBM50001103 |
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| Synonyms: | (2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid | (PMEA)[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | 9-(2-(phosphonomethoxy)ethyl)adenine | 9-[(2-phosphonylmethoxy)ethyl]adenine | 9-[2-(phosphonomethoxy)ethyl]adenine | 9-[2-phosphonomethoxyethyl]adenine | 9-[3-(Phosphonomethoxy)ethyl]adenine (PMEA) | ADEFOVIR | CHEMBL484 | GS-0393 | US10071110, Compound Adefovir | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid(PMEA) | [2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid | {[2-(6-AMINO-9H-PURIN-9-YL)ETHOXY]METHYL}PHOSPHONIC ACID |
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| Type | Small organic molecule |
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| Emp. Form. | C8H12N5O4P |
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| Mol. Mass. | 273.1857 |
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| SMILES | Nc1ncnc2n(CCOCP(O)(O)=O)cnc12 |
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| Structure | 
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