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TargetDihydrofolate reductase
LigandBDBM18792
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52998 (CHEMBL664429)
Ki 23±n/a nM
Citation Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem38:4739-59 (1996) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:23891.29
Organism:Pneumocystis carinii
Description:n/a
Residue:206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM18792
n/a
NameBDBM18792
Synonyms:1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine | CHEMBL747 | Chlorazin | Cycloguanil
TypeSmall organic molecule
Emp. Form.C11H14ClN5
Mol. Mass.251.715
SMILESCC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1 |t:3,6|
Structure
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