| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 5 |
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| Ligand | BDBM50032517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31713 (CHEMBL645373) |
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| EC50 | 610±n/a nM |
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| Citation |  Knoerzer, TA; Watts, VJ; Nichols, DE; Mailman, RB Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. J Med Chem38:3062-70 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 5 |
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| Name: | Adenylate cyclase type 5 |
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| Synonyms: | ADCY5_RAT | ATP pyrophosphate-lyase 5 | Adcy5 | Adenylate cyclase type 5 | Adenylate cyclase type IX | Adenylate cyclase type V | Adenylyl cyclase 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 139188.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_31725 |
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| Residue: | 1262 |
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| Sequence: | MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGA
VTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQR
RGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGT
VEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQ
SSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMG
LACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSA
LHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARL
HSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFT
SLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVE
MGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG
KAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKM
NRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEF
LGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQ
ITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGV
FTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGS
PQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD
LLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWK
LQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIAN
FSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDST
YDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW
GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPP
LS
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| BDBM50032517 |
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| n/a |
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| Name | BDBM50032517 |
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| Synonyms: | (6aR,12bS)-2-Ethyl-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridine-10,11-diol | CHEMBL104571 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO2 |
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| Mol. Mass. | 295.3755 |
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| SMILES | CCc1ccc2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3c2c1 |
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| Structure | 
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