| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gamma-aminobutyric acid type B receptor subunit 1/2 |
|---|
| Ligand | BDBM24186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_68425 (CHEMBL682871) |
|---|
| IC50 | 18±n/a nM |
|---|
| Citation |  Froestl, W; Mickel, SJ; Hall, RG; von Sprecher, G; Strub, D; Baumann, PA; Brugger, F; Gentsch, C; Jaekel, J; Olpe, HR Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem38:3297-312 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gamma-aminobutyric acid type B receptor subunit 1/2 |
|---|
| Name: | Gamma-aminobutyric acid type B receptor subunit 1/2 |
|---|
| Synonyms: | GABA-B receptor | GABA-B receptor 1/2 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 68423 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Gamma-aminobutyric acid type B receptor subunit 1 |
|---|
| Synonyms: | GABA-B receptor | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABBR1 | GABR1_HUMAN | GARABR1 | GPRC3A | Gb1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 108337.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UBS5 |
|---|
| Residue: | 961 |
|---|
| Sequence: | MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVD
YEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLP
ALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSG
GWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKI
ILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKL
FEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDAR
IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE
GHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALA
LNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIE
QLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSS
LGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFP
FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM
DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL
LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA
IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEK
IIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLY
K
|
|
|
|---|
| Component 2 |
| Name: | Gamma-aminobutyric acid type B receptor subunit 2 |
|---|
| Synonyms: | GABA-B receptor | GABBR2 | GABR2_HUMAN | GPR51 | GPRC3B |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 105844.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EBI_100031 |
|---|
| Residue: | 941 |
|---|
| Sequence: | MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMG
LMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA
IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN
AVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSV
KKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSS
RCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYD
GIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG
ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLP
LYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLD
GSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI
VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIV
YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQ
FCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSV
NQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL
GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILH
HAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
|
|
|
|---|
| BDBM24186 |
|---|
| n/a |
|---|
| Name | BDBM24186 |
|---|
| Synonyms: | (3-amino-2-hydroxypropyl)phosphinic acid | 3-aminopropylphosphinic derivative, (R)-3 | 3-aminopropylphosphinic derivative, (S)-3 | 3-aminopropylphosphinic derivative, 3 | CGP35583 | CHEMBL113453 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C3H8NO3P |
|---|
| Mol. Mass. | 137.0743 |
|---|
| SMILES | NCC(=O)CP(O)O |
|---|
| Structure | 
|
|---|
Search and Browse
