| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin receptor type B |
|---|
| Ligand | BDBM50034263 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63705 (CHEMBL676631) |
|---|
| IC50 | 417±n/a nM |
|---|
| Citation |  Doherty, AM; Patt, WC; Edmunds, JJ; Berryman, KA; Reisdorph, BR; Plummer, MS; Shahripour, A; Lee, C; Cheng, XM; Walker, DM Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J Med Chem38:1259-63 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin receptor type B |
|---|
| Name: | Endothelin receptor type B |
|---|
| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49664.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
|---|
| Residue: | 442 |
|---|
| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
|---|
| BDBM50034263 |
|---|
| n/a |
|---|
| Name | BDBM50034263 |
|---|
| Synonyms: | CHEMBL25438 | PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-trimethoxy-benzyl)-but-2-enoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H25O9 |
|---|
| Mol. Mass. | 505.4932 |
|---|
| SMILES | COc1ccc(cc1)C(=O)C(\Cc1cc(OC)c(OC)c(OC)c1)=C(/C([O-])=O)c1ccc2OCOc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
