| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50034453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63217 (CHEMBL674069) |
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| IC50 | 130±n/a nM |
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| Citation |  Stein, PD; Floyd, DM; Bisaha, S; Dickey, J; Girotra, RN; Gougoutas, JZ; Kozlowski, M; Lee, VG; Liu, EC; Malley, MF Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists. J Med Chem38:1344-54 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50034453 |
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| n/a |
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| Name | BDBM50034453 |
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| Synonyms: | 5-Methylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | CHEMBL27370 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N3O3S |
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| Mol. Mass. | 331.389 |
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| SMILES | CNc1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C |
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| Structure | 
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