| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50291957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196279 (CHEMBL806633) |
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| KOFF | 0.000234 s-1 |
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| KON | 8.63 M-1s-1 |
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| Citation |  Morelock, MM; Pargellis, CA; Graham, ET; Lamarre, D; Jung, G Time-resolved ligand exchange reactions: kinetic models for competitive inhibitors with recombinant human renin. J Med Chem38:1751-61 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50291957 |
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| n/a |
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| Name | BDBM50291957 |
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| Synonyms: | (R)-2-(2-Amino-thiazol-4-ylmethyl)-N*4*-cycloheptylmethyl-N*1*-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N*4*-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide | CHEMBL50851 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H64N6O5S |
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| Mol. Mass. | 741.038 |
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| SMILES | CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC(=O)N(CC1CCCCCC1)CC(=O)N(C)CCc1ccccn1)Cc1csc(N)n1 |
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| Structure | 
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