| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM50035204 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_177000 (CHEMBL779290) |
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| IC50 | 10000±n/a nM |
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| Citation |  Hartmann, RW; Bayer, H; Grün, G; Sergejew, T; Bartz, U; Mitrenga, M Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom. J Med Chem38:2103-11 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58260.64 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_224979 |
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| Residue: | 510 |
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| Sequence: | MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWL
KMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRR
MHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLE
ALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSM
FKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIV
AALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEAS
IAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSM
GRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQV
ETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
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| BDBM50035204 |
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| n/a |
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| Name | BDBM50035204 |
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| Synonyms: | 4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-pyridine | 4-(6-methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)pyridine | CHEMBL294361 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17NO |
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| Mol. Mass. | 251.323 |
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| SMILES | COc1ccc2CCC3C(C3c2c1)c1ccncc1 |
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| Structure | 
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