| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50403547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956583 (CHEMBL2380033) |
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| Ki | 2.18±n/a nM |
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| Citation |  Bhattacharjee, AK; Pomponio, JW; Evans, SA; Pervitsky, D; Gordon, RK Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg Med Chem21:2651-62 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 66151.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20309 |
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| Residue: | 590 |
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| Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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| BDBM50403547 |
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| n/a |
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| Name | BDBM50403547 |
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| Synonyms: | ATROPEN | ATROPINE |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23NO3 |
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| Mol. Mass. | 289.3694 |
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| SMILES | CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1 |r,THB:9:7:1:3.4| |
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| Structure | 
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