| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50491132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956584 (CHEMBL2380034) |
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| Ki | 5.85±n/a nM |
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| Citation |  Bhattacharjee, AK; Pomponio, JW; Evans, SA; Pervitsky, D; Gordon, RK Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg Med Chem21:2651-62 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
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| Type: | GPCR |
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| Mol. Mass.: | 51730.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08172 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50491132 |
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| n/a |
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| Name | BDBM50491132 |
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| Synonyms: | CHEMBL2377261 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29NO3 |
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| Mol. Mass. | 355.4706 |
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| SMILES | CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C |
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| Structure | 
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