| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50036074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63984 (CHEMBL677610) |
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| Ki | 290±n/a nM |
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| Citation |  Veale, CA; Damewood, JR; Steelman, GB; Bryant, C; Gomes, B; Williams, J Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones. J Med Chem38:86-97 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50036074 |
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| n/a |
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| Name | BDBM50036074 |
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| Synonyms: | 2-(1-Oxo-1,9-dihydro-beta-carbolin-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide | CHEMBL367631 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18F3N3O3 |
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| Mol. Mass. | 393.3597 |
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| SMILES | CC(C)C(NC(=O)Cn1ccc2c(nc3ccccc23)c1O)C(=O)C(F)(F)F |
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| Structure | 
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