Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor

Ligand

BDBM50036186

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138314 (CHEMBL743825)

2700±n/a nM

Citation

Nilsson, BM; Sundquist, S; Johansson, G; Nordvall, G; Glas, G; Nilvebrant, L; Hacksell, U 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. J Med Chem38:473-87 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor

Name:

Muscarinic acetylcholine receptor

Synonyms:

GPM3 | Muscarinic acetylcholine receptor M3

Type:

n/a

Mol. Mass.:

66272.13

Organism:

Cavia porcellus

Description:

n/a

Residue:

587

Sequence:

MTLHSNSTTLPLFPNISTSWIHSPSEAGLPPGTVTHFGSYNISQAAGNFSSLNGTTSDPL
GGHTIWQVVFIAFLTGFLALVTIIGNILVIVSFKVNKQLKHVNNYFLLSLADLIIGVISM
NLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT
KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM
PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSLKH
SSRRKYSRCHFWFATKSWKPNAGQMDQDHSSSDSWNNYDAAASLENSASDEEDIGSETRA
IYSIVLKLPGHSTILNSTKLPSSDNLQVPEEDLEPMDMERNASKPQTQKSMDDGGSFQKS
FSNLPIQLESTMDTAKTSDANSSVSKTMATLPLSFKEATLAKRFALRTRSQITKRKRMSL
IKEKRAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVC
YALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL

BDBM50036186

n/a

Name

BDBM50036186

Synonyms:

3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL145081

Type

Small organic molecule

Emp. Form.

C15H17NOS

Mol. Mass.

259.367

SMILES

OC1(CN2CCC1CC2)c1csc2ccccc12 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.31,-16.66,;5.76,-17.19,;6.72,-15.98,;8.25,-15.88,;8.94,-14.5,;8.07,-13.22,;6.55,-13.33,;5.87,-14.69,)|

Structure