Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor

Ligand

BDBM50036194

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138314 (CHEMBL743825)

1400±n/a nM

Citation

Nilsson, BM; Sundquist, S; Johansson, G; Nordvall, G; Glas, G; Nilvebrant, L; Hacksell, U 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. J Med Chem38:473-87 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor

Name:

Muscarinic acetylcholine receptor

Synonyms:

GPM3 | Muscarinic acetylcholine receptor M3

Type:

n/a

Mol. Mass.:

66272.13

Organism:

Cavia porcellus

Description:

n/a

Residue:

587

Sequence:

MTLHSNSTTLPLFPNISTSWIHSPSEAGLPPGTVTHFGSYNISQAAGNFSSLNGTTSDPL
GGHTIWQVVFIAFLTGFLALVTIIGNILVIVSFKVNKQLKHVNNYFLLSLADLIIGVISM
NLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT
KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM
PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSLKH
SSRRKYSRCHFWFATKSWKPNAGQMDQDHSSSDSWNNYDAAASLENSASDEEDIGSETRA
IYSIVLKLPGHSTILNSTKLPSSDNLQVPEEDLEPMDMERNASKPQTQKSMDDGGSFQKS
FSNLPIQLESTMDTAKTSDANSSVSKTMATLPLSFKEATLAKRFALRTRSQITKRKRMSL
IKEKRAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVC
YALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL

BDBM50036194

n/a

Name

BDBM50036194

Synonyms:

2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHEMBL144434

Type

Small organic molecule

Emp. Form.

C13H15NO

Mol. Mass.

201.2643

SMILES

Oc1ccccc1C1=CN2CCC1CC2 |t:8,(10.48,-5.39,;11.15,-4.01,;12.7,-3.91,;13.38,-2.54,;12.53,-1.25,;10.99,-1.34,;10.31,-2.72,;8.84,-3.12,;8.84,-4.67,;7.49,-5.32,;6.87,-4.06,;7.81,-3.59,;7.5,-2.35,;6.17,-3.12,;6.17,-4.67,)|

Structure