Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50036448

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1200 (CHEMBL615966)

271±n/a nM

Citation

Haadsma-Svensson, SR; Svensson, K; Duncan, N; Smith, MW; Lin, CH C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability. J Med Chem38:725-34 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50036448

n/a

Name

BDBM50036448

Synonyms:

(3aR,9bS)-3-(3-Methyl-but-2-enyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide | CHEMBL355601

Type

Small organic molecule

Emp. Form.

C18H24N2O

Mol. Mass.

284.396

SMILES

[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]-[#6@@H]-2-[#6@H]-1-[#6]-[#6]-c1cccc(-[#6](-[#7])=O)c-21

Structure