| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50491873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961530 (CHEMBL2388561) |
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| Ki | 86000±n/a nM |
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| Citation |  Dana, D; Davalos, AR; De, S; Rathod, P; Gamage, RK; Huestis, J; Afzal, N; Zavlanov, Y; Paroly, SS; Rotenberg, SA; Subramaniam, G; Mark, KJ; Chang, EJ; Kumar, S Development of cell-active non-peptidyl inhibitors of cysteine cathepsins. Bioorg Med Chem21:2975-87 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50491873 |
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| n/a |
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| Name | BDBM50491873 |
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| Synonyms: | CHEMBL2387617 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12O3S |
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| Mol. Mass. | 212.265 |
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| SMILES | CCc1ccccc1S(=O)(=O)C1CO1 |
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| Structure | 
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