| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50036806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146647 (CHEMBL754931) |
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| IC50 | 127±n/a nM |
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| Citation |  Pitzele, BS; Hamilton, RW; Kudla, KD; Tsymbalov, S; Stapelfeld, A; Savage, MA; Clare, M; Hammond, DL; Hansen, DW Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. J Med Chem37:888-96 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40465.04 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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| BDBM50036806 |
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| n/a |
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| Name | BDBM50036806 |
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| Synonyms: | 2-Amino-3-[2,6-dimethyl-4-(4-nitro-benzyloxy)-phenyl]-N-[(R)-1-(3-phenyl-propylcarbamoyl)-ethyl]-propionamide | CHEMBL353806 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36N4O5 |
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| Mol. Mass. | 532.6306 |
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| SMILES | C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)[N+]([O-])=O)cc1C)C(=O)NCCCc1ccccc1 |
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| Structure | 
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